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[DOI] [PMC free article] [PubMed] [Google Scholar] 243.Bechard ME, Smalling R, Hayashi A, Zhong Y, Word AE, Campbell SL, Tran AV, Weiss VL, Iacobuzio-Donahue C, Wellen KE, and McDonald OG (2020)

doi: 10.3390/cimb45100489 82 DuYDreyfusCF

While early preclinical data show promise, its crucial to understand that BPC157 is not federally approved for human use, and nearly all products available to consumers are unregulated research chemicals

The signaling pathway involving STAT3/Nrf2/GPX4 is integral to the resistance observed in osteosarcoma cells and may serve as a promising therapeutic target to improve the effectiveness of cisplatin against bone tumors ( Figure 6 ) (191)
