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Although antioxidants could scavenge free radicals, quantities of ROS would be accumulated when the antioxidants are exhausted

Knop FK

The interplay among iron accumulation, oxidative stress, and neuroinflammation can create vicious cycles that reprogram cellular metabolism and disrupt the critical metabolic coupling between neurons and glial cells
doi: 10.3390/jcm10235677 [DOI] [PMC free article] [PubMed] [Google Scholar] 132
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