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Moreover, although preclinical studies have yielded promising results, large-scale, double-blinded clinical trials remain necessary to verify the therapeutic efficacy and feasibility of these approaches in DN patients
Benvenga S, Ruggeri RM, Russo A, et al
J Pharmacovigil
However, a more recent study has shown that the deletion of Atgl in both SSCs and BMAds using the Prx1-Cre system resulted in compromised HSC regeneration and lymphoid differentiation after irradiation (214), indicating an important role of BMAd lipolysis in this process
