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In a mouse model of AD, treatment with EGCG-loaded nanoparticles (EGCG-NPs) was associated with decreased expression of necroptosis-related markers including RIPK1, RIPK3, and MLKL, as well as a reduction in Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling- (TUNEL-) positive keratinocytes, suggesting potential inhibition of keratinocyte necroptosis ( AICD is a specialized form of programmed cell death that occurs in chronically stimulated T cells following prolonged antigen exposure, serving as a critical mechanism to maintain immune homeostasis and peripheral tolerance (Zhang et al., 2000

Multiple Sclerosis and Related Disorders 3:696704 [DOI] [PubMed] [Google Scholar] 155.Saha K, Jaenisch R (2009) Technical challenges in using human induced pluripotent stem cells to model disease

Insulin and multiple growth factors acting via RTKs support neuronal survival programs [110,111,112]