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These hallmark lesions appear years, if not decades, before symptom onset and are associated with synaptic dysfunction, progressive neuronal loss, and widespread cortical and hippocampal atrophy
16 One of the major advantages of these novel criteria was probably to allow an earlier diagnosis of the disease
For example, by activating TSPO and the Kv7.2/3 channel simultaneously, researchers were able to promote axon growth in dorsal root ganglion (DRG) neurons in a spine injury model [31]
Wilken M
