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Description
Mutations in the human CLPP gene can cause Perrault syndrome, among others
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While Atorvastatin revolutionized cholesterol management, its lipophilic lactone scaffold drives muscle toxicity, CYP3A4 clashes, and reactive liver metabolites that clash with precision medicine
NAMPT and NRK1/2 are also localized to the nucleus and cytosol 48,83,84 , suggesting that only the final step of salvage is performed in the mitochondria, with a mitochondrial NMN transporter, Slc25a45, recently proposed 85
