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Errarte P, Guarch R, Pulido R, Blanco L, Nunes-Xavier CE, Beitia M, et al

An extensive range of factors contributes to the development of resistance against anticancer drugs, including genetic mutations, altered epigenetics, enhanced drug efflux, and various changes in other molecular and cellular mechanisms, including the activation of specific signaling pathways (18, 3537)

This is primarily due to the avoidance of thermal damage caused by nanosecond laser stimulation, which can lead to cell death

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