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Models of greater injury severities in P11-P21 age ranges show axonal bulbs and varicosities with APP staining between 6 hours and 1 week (Adelson et al., 2001

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This is often temporary, but if it persists, you may want to adjust your timing or dose
Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)
