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While the finding that copper potently blocks 1 3 2 GABA A Rs suggests that this metal inhibits fast synaptic, or phasic GABAergic signalling in contrast to zinc, which can only inhibit tonic GABAergic signalling, it is important to note extrasynaptic receptors are sensitive to copper block and, therefore, tonic GABAergic signalling as well

The patients in the OFST group had a lower median number of days of antihistamine therapy compared to OG, and the difference was statistically significant ( p = 0.008) [65]

& Beynen, A.C., 2008

A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia