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Upon administration, the suppository base, usually made of substances like cocoa butter or a synthetic substitute, begins to melt at body temperature, releasing the active ingredient, glutathione, for absorption through the rectal mucosa
10.1016/j.clinthera.2020.09.008 302

Sorting nexin 10 (SNX-10), which plays a role in endo-lysosomal transport and stabilization, regulates CMA activity by enhancing LAMP2A stability

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