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Additionally, when activated, the SAPK/JNK pathway can trigger the P53-YAP1 pathway, decrease GPX4 levels, promote ROS accumulation, and increase susceptibility to ferroptosis [134-136]
doi: 10.1111/aji.13812 [DOI] [PubMed] [Google Scholar] 67
Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds (Fig
Chronic pain affects approximately 20% of the human population 42 and is recognized as a maladaptive condition involving central mechanisms 43,44,45,46,47
