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This enzyme dismutates the superoxide radical in the following reaction: 2O2* +2H+ SOD H2O2+O2 The hydrogen peroxide formed by SOD action can be detoxified by GSH-Px or CAT which reduce it to water as follows: H2O2 + 2GSH+GSH-Px GSSG+2H2O Catalase 2H2O2 2H2O + O2 Transition metal ions also accelerate the decomposition of lipid hydroperoxides into cytotoxic products such as aldehydes, alkoxyl radicals and peroxyl radicals

Searches were performed using a 50 ppm precursor ion tolerance for analysis

[DOI] [PubMed] [Google Scholar] 122.Sen S., Rao B., Wachnowsky C., Cowan J.A

ZSWIM8 displayed binding and polyubiquitylation activity towards another TDMD-competent AGO paralogue, human AGO1 (ref