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In a study by Momma et al., the view that VA is produced only by gut microbes was broken by co-incubating human serum, HUVEC cell lysate, or PON-transfected HEK293FT cell lysate with 3,4-DHPV (1500 M) at 37C, confirming that PON1/3 in serum can enzymatically hydrolyze 3,4-DHPV to VA by enzymatic hydrolysis, forming a new pathway of host metabolism (Momma et al., 2023)

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