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Description
In addition to mutation and overexpression of the biosynthetic genes and/or riboswitch sequences in the selected strains, the catalytic initiator of 5aminolevulinic acid (ALA), DMB, and cobalt ions were all introduced to enhance cobalamin production (NguyenVo et al., 2018)
It is the most common cause of cobalamin deficiency anaemia worldwide
Furthermore, high doses of regular vitamin C supplements cause gastrointestinal problems like abdominal cramps, bloating and diarrhoea
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