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For example, mutations in the Spike protein in Omicron cause the HLA-DRB1*03:01 allele to lose affinity for this protein [390]
Neutralization of tumor acidity improves antitumor responses to immunotherapy
However, under sustained TGF-1 stimulation, Smad7 is frequently degraded, leading to failure of the anti-fibrotic braking mechanism [145, 146]
