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The oral administration of NPT200-11 resulted in brain concentrations of 10 mg/kg, but this increased availability in the brain did not translate into a significant improvement in the symptomatology compared with that of the original molecule [320]

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Although it has been demonstrated that Epitalon exerts, among other effects, a direct influence on melatonin synthesis, alters the mRNA levels of interleukin-2, modulates the mitogenic activity of murine thymocytes, and enhances the activity of various enzymes, including AChE, BuChE, and telomerase, it remains uncertain whether these are the sole mechanisms of action of this compound