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The effect on mitochondria is supported by pretreatment of pancreatic -cells with micromolar concentrations of acetylcarnitine, which protected the cells from oleic acid-induced mitochondrial dysfunction and decreasing ROS production [120]
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Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]
