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Description
Although not examined here, it would be interesting to understand if the clean off-target profile for MP-616 translates into fewer side-effects in vivo, especially considering the poly-pharmacology observed with ALRN-6924 at higher doses in the counterscreen line, Ca Ski (Table 2)
The tripeptide itself is stable, but the copper complex requires careful handling to maintain the metal-peptide association
The magnitude of these changes, 8.6mm Hg for SBP and 3.1 mm Hg for DBP, represents a clinically relevant reduction in a patient population which is considered difficult to treat
2019;7(2):606-615.e9
