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For example, lactate transport across the BBB can provide ~8%10% of the brains energy requirements and has been estimated to supply ~20%25% of energy at the expense of glucose consumption during energy demanding activities

During parasitemia, upon degrading the erythrocyte, ferriprotoporphyrin IX (hemozoin) becomes toxic to the parasite, which, using the polymerization process, converts it into an inert pigment, hemozoin

In particular, they pointed out that although NRF2 has been traditionally considered as a tumor suppressor because of its cytoprotective functions [320], a growing number of studies have shown a strong NRF2 activation at certain stages of cancer [318, 321]

[PubMed] [Google Scholar] Hinchman C.A., Truong A.T., Ballatori N