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Improvement in disturbed sleeping patterns: Epithalon normalizes melatonin secretion in older patients, with downstream benefits for sleep quality
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University of Rochester
They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption
