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If the ROS concentration easily reaches a threshold, it causes oxidative damage and leads to aging
Paul, S., Feoktistov, I., Hollister, A
During ferroptosis, triggering stimuli can activate the process of ferritin degradation, termed ferritinophagy, or lead to the degradation of SLC40A1, thereby augmenting the levels of cytoplasmic Fe 2+ within unstable iron pools in cancer cells [104,105,106]
Nonetheless, the forced overexpression of GPx1 has been shown to suppress cellular proliferation and migration of pancreatic cancer cells [133, 134], suggesting that GPx1 is a tumor suppressor in some cancers
