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H 2 O 2 -treated zygotes had elevated levels of ROS, as well as increased oxidative damage, activation of the G2/M checkpoint, decreased cleavage and blastocyst rates, and increased rates of apoptosis

doi: 10.3389/fbioe.2022.824859 Received 29 November 2021 Accepted 04 January 2022 Published 25 January 2022 Volume 10 - 2022 Edited by Zhi-Qiang Liu, Zhejiang University of Technology, China Reviewed by Tobias Klein, Hochschule Kaiserslautern University of Applied Sciences, Germany Xiaolin Shen, Beijing University of Chemical Technology, China Xusheng Chen, Jiangnan University, China Updates Copyright 2022 Zhang, Liang, Zhao, Ma, Luo, Li and Xu

Conversely, in 20.6% of the samples, neither a declared API nor any API was identified

SFN and other isothiocyanates (ITCs) target HDAC turnover and activity, increasing the acetylation of histone substrates and leading to TSG activation (Gao and Tollefsbol 2015)