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Description
Defects in enzymes of the -glutamyl cycle To date, hereditary defects have been described in four of the major enzymes that mediate GSH metabolism through the -glutamyl cycle [66]

[DOI] [PMC free article] [PubMed] [Google Scholar] Zheng H, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang D, Zhang DD

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This strategy is the basis for many anticancer therapeutics, including chemotherapeutics, radiotherapies, and most small-molecule inhibitor-based therapies, which impair tumor metabolism and induce excessive ROS accumulation, inducing cell toxicity and death