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Despite the limitation of only two individuals, CIT and DH-CIT appear to be suitable biomarkers for exposure assessment based on urine and blood analysis (Ali and Degen 2019)
For example, the deletion of p53 prevents the nuclear accumulation of dipeptidyl peptidase-4 (DPP4), thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis
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