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doi: 10.1016/j.archger.2016.01.006
cardiovascular system (eg, increased risk of arterial obstruction, hypertension, stroke, atherosclerosis, heart attacks, and increased inflammation)
Finally, intrinsic and extrinsic pathways can activate a common effector CASP (e.g., CASP3 or CASP7) to trigger apoptosis
In the solid tumor niche, particularly in areas with increased inflammatory activity, T cells often encounter an environment with abundant reactive oxygen species (ROS), which substantially impair T cell activation, proliferation and effector differentiation
