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This neuroimmune regulatory pathway was critical for reducing systemic responses and lung injury in a polymicrobial sepsis model and involved downstream 1-adrenergic and opioid receptor pathways [115]

Data extraction and synthesis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological transparency and rigor

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Together, they target the structural repair mechanisms that conventional medicine largely ignores: collagen synthesis, connective tissue remodeling, angiogenesis at the injury site, and nerve repair