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Histamine is the key inflammatory mediator, but other substances are also released by mast cells, including PAF, eicosanoids, prostaglandins, leukotrienes, substance P, and ROS

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2 Physiological influences of exercise on post traumatic stress disorder 2.1 Influences of exercise on the nervous system The effects of exercise on brain structure and function have been completely studied, in detail, in brain regions related to emotion regulation and stress response, like the amygdala and prefrontal cortex (Liang et al., 2021)

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