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Recently, a hypothesis has been proposed that may also implicate pathogens in the development of Downs syndrome (DS) and related Downs syndrome Alzheimers disease (DSAD) (Norins, 2022)

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Interestingly, S586A displayed an over 2-fold improvement in activity compared with the WT enzyme (96.0 2.0 Umg 1 versus 43.1 1.0 Umg 1 ), representing the highest activity among all variants tested