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Even though tyrosine kinase inhibitors are commonly associated with the cutaneous side effects of skin and hair depigmentation, there have been rare cases of hair repigmentation

As to animal models, the anatomical structure and physiological characteristics of rodent eyes (C57BL/6 mice or Sprague-Dawley rats) differ significantly from those of humans

In this regard, PX-478 was reported active in a panel of cell lines with prominent selectivity towards inhibition of HIF-1 protein translation 87

Available from: Mechler et al (2022): Evidence-based pharmacological treatment options for ADHD in children and adolescents