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A 2011 systematic review of clinical data suggested that citicoline could hasten the resorption of cerebral edema and improve the recovery of consciousness and neurologic disorders in severe TBI cases (classified by Glasgow Coma Scale [GCS] scores of 8) (5)

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Clin Ther 38:12631271 Cotel F, Exley R, Cragg SJ, Perrier J-F (2013) Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

Efficacy and safety of opicinumab in participants with relapsing multiple sclerosis: a randomized, placebo-controlled, phase 2 trial (AFFINITY part 1)
