klowa Nikaia & Mountains from Kwoiek Creek - Aug 20 16 Meghan Fandrich (@klowa_handknits) • Instagram

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Surmeier DJ, Guzman JN, Sanchez-Padilla J, Schumacker PT (2011) The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinsons disease

Although the molecular mechanisms underlying these differences are not clear, data from experimental models suggests that estrogen deficiency results in the activation of several regulatory mechanisms such as the renin-angiotensin-aldosterone axis, which lead to the development of cardiac hypertrophy and fibrosis (Benjamin et al., Aging-Related Heart Alterations Aging-associated cardiac remodeling is characterized by increased oxygen and energy demand due to elevated afterload and hypertrophy of cardiomyocytes (Lakatta and Levy, 2003b)