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Description
Since elevated glutamate levels are linked to relapse, study authors were encouraged by the findings
The enzyme is complex, with four copper atoms, two or more disulfides, glycosylation, optimal activity at acidic pH (pH 45) and an electron transfer pathway that is strongly interrupted by modest concentrations of hydroxyl anions or halides (for example, NaCl and KCl) in cell culture media 21

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, and Piwnica-Worms D 2009

Postnatal mechanisms have been proposed, including immune dysregulation, gastrointestinal abnormalities, oxidative stress, and neural circuit differences, though these remain largely unproven and are the focus of ongoing research
