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Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo

In our study, Nrf2 WT and KO thyroid organoids differentiated with TSH instead of cAMP showed the same down-regulation in Tg mRNA expression, suggesting that the effect is mainly driven by the lack of Nrf2 biding to the ARE sequence of Tg promoter

Although hydrogels can adapt to different shapes of defects, their mechanical properties are relatively poor [90]

Active backend strategies include taking antiviral compounds, dampening inflammation, and supporting antioxidative functions