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With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis

GPX3 expression in primary human bronchial epithelial cells and lung fibroblasts was downregulated by TNF-, but more variably regulated by TGF-1 and menadione

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