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These mutants also display abnormal ERG b-waves, suggesting an inhibition of the ON-retinal pathway at the level of bipolar cells (Masu et al., 1995)

Researched applications In the published preclinical and clinical literature the effects of Cagrilintide are documented in the following areas: Obesity (stand-alone) , Phase 2 data (Lau 2021, 10.8 % at 4.5 mg) Obesity + Semaglutide (CagriSema) , Phase 3 REDEFINE 1 (25.3 %) T2DM + obesity , Phase 3 REDEFINE 2 Cardiovascular prevention , Phase 3 REDEFINE 3 (n ~ 7000) MASLD/MASH , exploratory in Phase 2 Type 2 diabetes (monotherapy) , preclinical data Prediabetes , exploratory plans Science & studies 4.1 Key publications Lau D.C.W., Erichsen L., Francisco A.M., et al

Research investigations commonly explore the compound in experimental models examining: Cellular regulatory signalling pathways Peptide-mediated molecular communication Intracellular regulatory network modelling Biological rhythm signalling research Comparative regulatory peptide studies Molecular signalling pathway dynamics Experimental peptide interaction research Research Applications In controlled research environments, Epitalon may be utilised in experimental models designed to explore cellular regulatory systems and peptide signalling pathways