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Generally, AgNP cytotoxicity depends on the dose, time, temperature, surface coatings, size, and cell type (Mousavi-Kouhi et al., 2021a)

Causes of systemic low-grade inflammation may include tissue aging (inflamm-aging) [825,826]

129 The process of ubiquitination begins with the activation of ubiquitin by ubiquitin-activating enzymes (E1s), which transfer the activated ubiquitin to ubiquitin-conjugating enzymes (E2s)

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