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The results are also consistent with the idea that SL11 and Lops4 are orthologous crystallins representing the first descendants of the ancestral GST gene in the pathway which gave rise to the extensive S-crystallin family of lens proteins

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Gao V, Suzuki A, Magistretti PJ, Lengacher S, Pollonini G, Steinman MQ, et al

Increased IR expression and glycolysis restriction led to the functional and metabolic exhaustion of diabetogenic T cells independent of PD-1 and LAG-3 signaling, as checkpoint blockade failed to reverse this phenotype ( Figure 7 )