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A few properties are shown to correlate with high statistical significance, including hydrogen bond acceptor, conformational flexibility (number of rotatable bonds), amide bond, polar surface area, polarizability, saturated carbon atoms, larger molecular size, and less globularity, which correlate with a higher chance of chemicals being recognized by TolC

Mechanistic studies reveal that SFN significantly downregulates programmed death-ligand 1 (PD-L1) expression on tumor cells through multiple mechanisms, including direct covalent modification of cysteine residues on STAT1, which inhibits its transcriptional activity and blocks IFN--induced PD-L1 expression (75)

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