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In advanced cirrhosis, there is impairment of the function and maturation of DCs, which has been shown to be related to an imbalance of extracellular branched-chain amino acids(BCAAs) (108)
Additionally, ATF3 regulates genes such as acyl-CoA synthetase long chain family member 4 and lipoxygenases, essential for producing and incorporating PUFAs into cellular membranes, which is a critical step in lipid peroxidation (119121)
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