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Another benefit is that fractionation increases the likelihood that cancer cells will be exposed to radiation at the points in the cell cycle when they are most susceptible to DNA damage (Schreiber 2013)

In summary, androgens/AR signaling regulates mitochondrial biogenesis by enhancing the PGC-1/NRF-1/TFAM pathway and affecting mtDNA copy number and OXPHOS through localization to mitochondria

These mechanistic insights support DRP1-dependent mitochondrial fission as a promising therapeutic target for RP requiring further validation

The binding of CD40 on OFs and CD40L (CD154) on T cells in TED patients leads to OFs proliferation, and blocking CD40 or CD40L significantly reduces OFs proliferation