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aureus colonization and persistence by disrupting skin barrier integrity through the downregulation of epidermal barrier genes ( Beyond keratinocytes, oxidative stress also influences various immune cells
10.1158/0008-5472.CAN-14-3603 17
Consequently, targeting FLT3 mutations could be an effective strategy to reactivate ceramide pathways and promote apoptosis in AML cells [140]

The issue is cumulative exposure over time
