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For instance, in the yeast Candida albicans , continuous exposure to hypoxic conditions decreased mtDNA methylation (18)

Conversely, mice with heart-specific overexpression of MT-IIa are protected against intermittent hypoxia-induced cardiomyopathy (Yin et al., 2014)

In yet another study, increases in the levels of glutathione peroxidase and SOD were dependent on the sample analyzed (plasma or erythrocytes) and clinical manifestations (depression with or without melancholia), suggesting that various factors affect the extent of changes in the activity of antioxidant enzymes in depressed patients [97]
Toxic action/toxicity