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Scalea et al., 2007
10.1007/s11357-019-00137-4 60
GraphPad Prism 7.00 software was used to perform all statistical analyses
MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)
