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CAFs contribute to tumor angiogenesis through secretion of angiogenic factors, whilst via production of SDF-1 they recruit bone-marrow endothelial progenitor cells (VEGF-independent mechanism) (117)

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(1994) Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation