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Hybrid Responsive Nanocarriers Lipid polymer hybrids combine a lipid core that interacts well with cell membranes with a polymer shell that provides mucoadhesion and stability Likewise, potent therapeutic compound with high aqueous solubility, was successfully encapsulated into polymerlipid hybrid nanoparticles (PLHNs)

Despite this physical separation, gut microbiota can deeply modulate epithelial cells and the immune system ( de novo synthesized metabolites such as short-chain fatty acids (SCFAs)