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It is possible that dysregulated glutathione metabolism in mitochondria may promote necroptosis by altering the function of PGAM5 (phosphoglycerate mutase family member 5) and DRP1 (dynamin-related protein 1), mitochondrial proteins that are known to be associated with the necrosome (21, 22)

This can increase the risk of heart disease, osteoporosis, high blood pressure, and type 2 diabetes

These studies should also aim to establish the optimal dose when metformin is used alongside current TB therapies, as well as its potential role in shortening treatment duration and enhancing prophylactic control of TB