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3 Inserting exogenous genes 3.1 GM-CSF Induction of immune cells to kill tumor cells is one of the key mechanisms of oncolytic virus anticancer
Key publications include the original characterization study (PubMed: 930790), stress response research (PubMed: 7540925), and neuroendocrine effects (PubMed: 2547858)
Core manifestations include bradykinesia, resting tremor, and muscular rigidity, but non-motor symptoms (such as constipation, hyposmia, depression, cognitive decline, and sleep disturbances) also significantly impact quality of life (150)
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