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Keywords: Metformin, Vitamin B12 deficiency, Metformin-induced cobalamin deficiency, Diabetes, Type 2 diabetes, Prediabetes, Screening criteria, Neuropathy, Anemia Core Tip: Over the last decades, vitamin B12 deficiency has been increasingly recognized as a possible consequence of long-term metformin therapy, potentially resulting in clinical manifestations such as hematologic abnormalities and peripheral neuropathy

The decline of normal red blood cell production, caused by low levels of vitamin B12, can impair oxygen delivery

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