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Introduction The incidence of obesity has risen alarmingly in recent years, and it is starting to overtake malnutrition and infectious disease as the major threat to global public health ( Probiotics are active microorganisms that help the hosts health after adequate administration ( Lactobacillus and Bifidobacteria have been proven to exhibit favorable effects on lipid metabolic disorders including obesity and NAFLD through regulation of energy metabolism, inflammatory response, and intestinal barrier function ( Limosilactobacillus ( Lactobacillus ) fermentum CECT5716 (5 10 8 CFU/d, 11 weeks) resulted in an obvious anti-obesity effect via amelioration of endothelial and intestinal barrier dysfunction in HFD-induced obese mice ( Bifidobacteria breve B-3 (10 8 or 10 9 CFU/d, 8 weeks) in HFD-feeding mice dose-dependently suppressed body weight gain and fat accumulation ( Over time, evidence has accumulated in support of the important role that gut microbiota plays in host energy metabolism and the development of obesity ( via competitive exclusion of pathogens and producing antimicrobial substances, thus improving gut dysbiosis and host metabolic homeostasis ( Brevibacillus laterosporus , a pathogen of invertebrates, produces various antimicrobial substances such as polyketides, non-ribosomal peptides, antibiotics, and chitinase, resulting in broad-spectrum antimicrobial activity ( B