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Since melanogenesis causes the production of skin pigment, its inhibition leads to the whitening of the entire skin

(2024), and others have shown that selenium gluconate (SeGlu) derivatives, novel organic selenium compounds, reduce the abundance of detrimental bacteria such as Rikenella, Barnesiella, Tenacibaculum, Acinetobacter, Bacteroides, and Alistipes, while increasing beneficial microbes like Intestinimonas, Christensenella, Coprococcus, Butyrivibrio, Clostridium, Ruminococcus, Lactobacillus, and Lactococcus

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We evaluate the current limitations in our understanding of the mechanism of MAT2A/PRMT5 inhibitors and identify the challenges that must be addressed to maximise the potential of these drugs